![]() ![]() organs/tissues) via material balances on homogeneous compartments. The combined model accounts for skin transport via diffusion equations, and absorption and distribution in the rest of the body (i.e. ![]() The skin model features three strata: stratum corneum, viable epidermis, and dermis, which have a major impact on the absorption, distribution, and metabolism of transdermal drugs. This is achieved by an innovative combination of the physiologically-based compartmental approach with Fick’s laws of diffusion. This paper proposes a model for the study and prediction of drug transport through skin and the following distribution to human body. ABSTRACT: There is a significant hype in the medical sector for the transdermal administration of drugs as it allows achieving a combination of multiple advantages: non-invasive procedure, pain avoidance, no first-pass hepatic metabolism, and induction of sustained plasma levels.
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